Wine yeast sirtuins and Gcn5p control aging and metabolism in a natural growth medium
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چکیده
منابع مشابه
Wine yeast sirtuins and Gcn5p control aging and metabolism in a natural growth medium.
Grape juice fermentation by wine yeast is an interesting model to understand aging under conditions closer to those in nature. Grape juice is rich in sugars and, unlike laboratory conditions, the limiting factor for yeast growth is nitrogen. We tested the effect of deleting sirtuins and several acetyltransferases to find that the role of many of these proteins during grape juice fermentation is...
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Sirtuins are nicotinamide adenine dinucleotide (NAD)-dependent protein deacetylases that link protein acetylation, metabolism, aging, and diseases of aging. Sirtuins were initially found to slow aging in lower organisms and more recently shown to mediate many effects of calorie restriction on metabolism and longevity in mammals. This chapter focuses on two key mammalian sirtuins, SIRT1 (which r...
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The sirtuins are a family of proteins that act predominantly as nicotinamide adenine dinucleotide (NAD)-dependent deacetylases. In mammals seven sirtuin family members exist, including three members, Sirt3, Sirt4, and Sirt5, that localize exclusively within the mitochondria. Although originally linked to life-span regulation in simple organisms, this family of proteins appears to have various a...
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The importance of posttranslational modifications for sirtuin activities is discussed in the article “Regulation of sirtuin function by posttranslational modifications.” Here the authors review the posttranslational regulation mechanisms of mammalian sirtuins and discuss their relevance regarding the physiological processes. Based on available data they suggest that the Nand C-termini are the t...
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Blood vessels form the first organ in the developing embryo and build extensive networks that supply all cells with nutrients and oxygen throughout life. As blood vessels get older, they often become abnormal in structure and function, thereby contributing to numerous age-associated diseases including ischemic heart and brain disease, neurodegeneration, or cancer. First described as regulators ...
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ژورنال
عنوان ژورنال: Mechanisms of Ageing and Development
سال: 2012
ISSN: 0047-6374
DOI: 10.1016/j.mad.2012.03.013